ABSTRACT
The pretent study was performed to study the epiderrnal changes of ultraviolet irradiation and PUVA treatment in the black mice. The following results were obtained: 1) The histologic changes of the epidermis, number of DOPA positive melanocytes and ultrastructural changes of keratinocytes due to UVB and PUVA were rnore prominent than those of UVA irradiation. 2) The histological changes after 8-MOP photosensitization closely mirnic those of UVR irradiation, and constant, finding was hyperkeratosis. 3) Early histological change after UVL irradiation & IUVA treatment was appearance of dytkeratotic cells. 4) Pro]onged exposure to UVB & PUVA resulted in transient epidermal hyperplasia, and epidermal atrophy occurred 3 weeks after PUVA treatment. 5) Early electron microscopic changes was perinuclear edema, juxtanuclear vacuoles and clumping of tonofilament.
Subject(s)
Animals , Mice , Atrophy , Dihydroxyphenylalanine , Edema , Epidermis , Hyperplasia , Intermediate Filaments , Keratinocytes , Melanocytes , Methoxsalen , Photosensitivity Disorders , Ultraviolet Rays , VacuolesABSTRACT
Pityriasis lichenoides chronica is characterized by unknown etiology, chronicity and by being essentially asymptomatic and refractory to therapy. Nine patients with pityriasis lichenoides chronica were treated with orally administrated 8-Methoxypsoralen and UVA irradiation(PUVA Therapy). After S-45 PUVA treatments, lesions were completely cleared.
Subject(s)
Humans , Methoxsalen , Pityriasis Lichenoides , Pityriasis , PUVA TherapyABSTRACT
Purpura fulminans (gangrenosa) is a rare clinical syndrome characterized by sudden appearance of rapidly progressive symmetrical subcutaneous ecchymosis durimg the convalescent stage of various infectious disease. A 4 year-old. boy has developed multiple skin defects with necrosis on extrernities and gangrenous changes on the left foot following a meningococcemia. B-K amputation on left leg and. free skin graft for multiple skin defect on extremities were, carried out.
Subject(s)
Child, Preschool , Humans , Male , Amputation, Surgical , Communicable Diseases , Ecchymosis , Extremities , Foot , Leg , Necrosis , Purpura Fulminans , Purpura , Skin , TransplantsABSTRACT
Epidermolysis bullosa dystrophica is a rare, chronic non-infIammatory mechanobullous disease of hereditsry trait, which easily produces bulla by minor injury or spontaneously. Bullae usually developed first at birth or in infancy, involving especially hands, feet, knees, elbows and other pressure sites, which heal with atrophic and hypertrophic scars, loss of hair and nails, digital fusion, flexural contractures of the knee, elbow and wrist joints. A 5-year-old boy has had various sized recurrent buIlae on hands, feet, kneces and elbows, healed with atrophy of skin, miliums, deformities of toe and finger nails. Diagnosis was confirmed by clinical features and electronmicroscopic findings. Literature were reviewed briefly.